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For the premiere, the show's producers tried rigorously to book Miami Vice's Don Johnson as the first guest, even trying to bribe him with Dom Pérignon and a pair of rhinestone sunglasses.
All attempts to book Johnson failed and Winfrey decided to "do what we do best, and that is a show about and with everyday people".
Winfrey was once again inspired to continue to help people take better control of their destinies, hence her slogan, "Live Your Best Life". And I realized that I had no right to quit coming from a history of people who had no voice, who had no power, and that I have been given this—this blessed opportunity to speak to people, to influence them in ways that can make a difference in their lives, and to just use that.
The show has been highly influential, and many of its topics have penetrated into the American pop-cultural consciousness.
Winfrey has used the show as an educational platform, featuring book clubs, interviews, self-improvement segments, and philanthropic forays into world events. Chicago, a half-hour morning talk show airing on WLS-TV, an ABC owned-and-operated station in Chicago.
Winfrey claims her worst interviewing experience was with Elizabeth Taylor in the show's second season.
Just before the interview, Taylor asked Winfrey not to ask any questions about her relationships.